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Older Men With Higher Testostero‚Äčne Levels Lose Less Muscle Mass as They Age

A recent study published in The Endocrine Society‘s Journal of Clinical Endocrinology & Metabolism (JCEM) found that higher levels of testosterone were associated with reduced loss of lean muscle mass in older men, even in those who were losing weight.

Higher testosterone levels were also associated with less loss of lower body strength.

Loss of muscle mass and strength contribute to frailty and are associated with accidental falls, mobility limitations and fractures.

Men lose more muscle mass and strength than women as they age, suggesting that sex steroids, and testosterone in particular, may contribute to body composition and physical function changes.

This study helps us better understand the relationship between testosterone levels and healthy aging in older men. The study showed that higher testosterone levels may help older men preserve muscle mass and delay frailty as they age.

“Our study finds that men, aged 65 years and older, with higher testosterone levels lost less muscle mass, especially in their arms and legs, than men this age who had lower testosterone levels,” said researchers from Kaiser Permanente Northwest in Portland, Oregon. They added “Men who had higher testosterone levels before they lost weight also lost less leg function and could stand up more easily from a chair than men who had lower testosterone levels before they lost weight.”

In this study, the researchers used data from 1,183 men aged 65 years or older and tested the hypothesis that higher baseline measures of sex steroids are associated with lesser declines in lean mass and maintenance of physical performance over an average follow-up of 4.5 years.

Body composition was measured using dual energy x-ray absorptiometry (DXA) scans and physical performance was measured through a series of exercises that assessed grip strength, lower extremity power, walking speed and the ability to rise from a chair without the use of arms.

“The amount of testosterone men have in their bodies may contribute to how much muscle and strength they lose as they get older,” they reported. “Our study adds evidence to the growing body of literature that suggest higher levels of endogenous testosterone may be favorably associated with some key components of healthy aging in men.”

The study included researchers from: Oregon Health & Science University in Portland; University of California, San Diego in La Jolla, CA; University of Pittsburgh in PA; and Stanford University in CA.

Story Source: The Endocrine Society.

Journal Reference: Higher Testosterone Levels Are Associated with Less Loss of Lean Body Mass in Older Men. Journal of Clinical

Endocrinology & Metabolism, 2011;

The Endocrine Society (2011, October 27). Older men with higher testosterone levels lose less muscle mass as they age.

This article is for informational and educational purposes only, and is not intended to provide medical advice, diagnosis or treatment. Contact your doctor or healthcare professional for medical and nutritional consultation.

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