By analyzing the hundreds of metabolicsubstances naturally present in the
liver,researchers at the University of California – Irvine Center for Epigenetics & Metabolism have discovered that circadian rhythms (our own body clock) greatly control the production of such key building blocks as amino acids, carbohydrates and lipids.
They identified more than 600 liver-originated metabolites, which are the chemical substances created by metabolism that sustain and promote cell health and growth. Approximately 60 percent of these metabolites were found to be dependent on the endogenous circadian clock while only about 15 percent of the body’s genes are regulated by it.
Circadian rhythms throughout 24 hours govern fundamental biological and physiological processes in almost all organisms.
They anticipate environmental changes and adapt certain bodily functions to the appropriate time of day. Disruption of these cycles can significantly affect human health.
Center for Epigenetics & Metabolism director Paolo Sassone-Corsi, recognized as one of the world’s preeminent researchers on circadian rhythms, led the new study… The liver metabolites reveal how the body clock through the main circadian gene, orchestrates the interplay between metabolites and signaling proteins. The process is similar to the way a conductor leads a symphony-orchestra to perfectly coordinate the instruments, brass and strings.
External cues such as day-night lighting patterns and nutrition influence the circadian system and metabolites. Their relationship to signaling proteins in cells seem to be acutely tied to circadian disruptions. This may help explain some of the primary physiological factors underlying obesity, high cholesterol and metabolic-based diseases like diabetes.
The results of the study appear in the online edition of the Proceedings of the National Academy of Sciences.
“By identifying the relationship between metabolites and the body clock, we have taken a first step toward a better understanding of how nutrients interact with our metabolism, giving researchers a new opportunity to spot the optimal times for us to get the fullest benefits from the foods we eat and the medications we take,” explained the researchers conducting the study.
Metabolic data about other tissues and conditions will be invaluable to further our understanding of the interplay between metabolism and circadian rhythms in healthy and diseased states.” the researchers added Story Source: University of California – Irvine;
National Institutes of Health and National Science Foundation Journal Reference: Coordination of the transcriptome and metabolome by the circadian clock. PNAS, March 19, 2012 726109
University of California – Irvine (2012, March 19). Circadian rhythms have profound influence on metabolic output
This article is for informational and educational purposes only; It is not intended to provide medical advice, diagnosis or treatment. Consult your doctor or healthcare professional.
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