Nutritional Approaches Now Being Studied
For Helping Clear Brain Plaques Present in Alzheimer’s Disease
Alzheimer’s brain tissue exhibits many fewer nerve cells and synapses than a healthy brain, due to the presence of plaques (abnormal clusters of protein fragments) build up between nerve cells; tangled- twisted strands of proteins that contain dead and dying nerve cells.
In a study from the University of California Los Angeles (UCLA; California, USA), researchers drew blood samples from both Alzheimer’s patients and healthy patients. They isolated macrophages , which are the blood components that are responsible for disposing of amyloid-beta and other waste products in the brain and body.
The team incubated the immune cells overnight with amyloid-beta. They added either an active form of vitamin D3 (1alpha,25-dihydroxyvitamin D3) or an active form of the omega-3 fatty acid DHA (resolvin D1) to some of the cells to gauge the effect they had on inflammation and amyloid-beta absorption.
The team observed that 1alpha, 25-dihydroxyvitamin D3 as well as the resolvin D1 improved the ability of the Alzheimer’s disease patients’ macrophages to devour amyloid-beta, and they also inhibited the cell death that is induced by amyloid-beta.
Researchers observed that each nutrition molecule utilized different receptors and common signaling pathways to accomplish this beneficial task. The researchers are reporting about the positive potential for nutritional approaches to fight Alzheimer’s, stating “Our new study sheds further light on a possible role for nutritional substances such as vitamin D3 and omega-3 in boosting immunity to help fight Alzheimer’s.”
(UCLA ; California, USA)